I really hated that kisara took the memory of shu and ayano doing it like I had hope that will be together but that hope was lost
I believe it's better this way, they have completely different aims in life. Shu lives for revenge and for finding his sister while Ayano just wants a normal life with him, which didn't work and will not.
I think relationships wise shu doesn't get with either of them in the end probably, my best guess is that shu and ayano will come to an agreement that they love eachother but simply cant be together because of conflicting futures which will lead to their downfall in the end anyways and kisara will probably understand the fact that shu probably wont love her in the end but she'll still pester him like shes doing now