What is the best anime to watch during a mid-life crisis?

Hoohokekyo Tonari no Yamadakun
Not really life altering but I think this movie has a good message about how much life you still have ahead of you and so many more new experiences to live through. Generally just a good vibes Ghibli movie!
Roujin Z
alternatively if you got your mid life crisis a bit late and/or your spine is reminding you of its existence, here are a bunch of geezers still kickin'. The movie criticizes how older people are treated in our society and tbh I think it applies to fiction just as well. There are just so few main characters who have clearly lived through a life.

As for healing, I think Mushishi is a good pick
Mushishi
To me its main message is about hope and light at the end of the tunnel, self acceptance and healing from past experiences

Gintama healed me through some tough times. The best anime of all time for me, its comedy is top notch and when it gets serious, it becomes quite competent and inspiring.

If you're not one for a super long show/Gintama doesn't interest you I can recommend Hajime No Ippo. The quintessential Shounen for me. Really motivating. Watching it makes you want to go out there and do something, it rekindles your self confidence.

Another anime that can also help you appreciate life is Rainbow: Nisha Rokubou no Shichinin. That anime was something else man, idk what it was but really felt nice watching it.

There's also the ever brilliant Steins;Gate. The more time passes the more that anime gets better to me, mostly because a lot of new anime try to go on a similar route but never come close to this anime's heights

If you want something that relates to children or parenthood or something I'd say the Maquia movie and Usagi Drop anime are great.

Idk about midlife crises but the ones I mentioned are all that can heal you, inspire you or just make you think about them for a long time. They stick with you and you just wonder if any other anime can top that. If you're ok with reading manga, Berserk and Helck are great. The berserk 1997 anime is good enough but the later ones are a disgrace and I haven't seen the Helck anime so can't comment on it but the manga was reinvigorating for the soul fr.

Haibane Renmei
idk how much of a mid-life crisis anime this is but it was a very therapeutic anime to watch for me so maybe it'll fit what you're looking for idk.

ARIA The ANIMATION
Barakamon

Shorts:
Kanojo to Kanojo no Neko Everything Flows
Honobono Log