With Okarun's balls intact and Turbo Granny gone its a major turning point since those were the running threads since the start. Very curious to see how things go from here.
I hope things are allowed to advance now and it doesn't go out of its way to revert to the status quo. Most manga's next chapter would be some contrivance to revert one or both of these changes, but I have faith in this mangaka.
I don't see a way that Turbo Granny would want to give her power back, but Ken's nuts are like super powerful so I'm hoping if he's going to gain some form of new power it would come from his own body this time.
Yeah I'm hoping he gets a whole new thing where he can stand on his own, and I'm pretty sure Granny is gonna end up sticking around, or in the very least become a commonly recurring support character.